CBD FOR ME
The cannabis receptor system has two kinds of receptors:• CB1 receptors – found mostly in the brain, spinal cord and other parts of the body including the heart, uterus, testis, liver, small intestine and peripheral cells
• CB2 receptors – found mostly on cells of the immune system, including the spleen, T-cells, B-cells and macrophages
A group of compounds, called cannabinoids, bind to the receptors. Cannabinoids come from three different places:
• Endocannabinoids – these are produced by the body on demand, usually in tesponse to injury; five different endocannabinoids have been identified, including anandamide and 2-AG
• Synthetic cannabinoids – these are produced by scientists in a laboratory and include dronabinol (Marinol) and nabilone (Cesamet)
• Phytocannabinoids – these are produced by the cannabis plant; there are over 85 cannabinoids in the cannabis plant, including THC and cannabidiol as the main two
The cannabinoids interact with the receptors, much like a lock and key. The receptor is the lock and the cannabinoid molecule is the key. When the cannabinoid "key” attaches to the receptor "lock” (located in the cell wall), a reaction is triggered resulting in an effect on the brain and body. For instance, the area of the brain that controls memories is called the amygdala. When cannabinoids bind to the receptors on the cells of the amygdala, memory is affected. For those that suffer from past traumatic events who relive horrible memories (such as those with Post Traumatic Stress Disorder), the triggering of the cannabinoid receptor appears to change the brain function and memories are minimized.
A study using weakly radioactive THC-like synthetic drugs investigated where the human cannabinoid receptors were located. When people were given this radioactive drug and their brains were scanned, CB1 receptors were found all over the brain. The results showed that cannabinoid receptor binding sites in the human brain are localized mainly in: the forebrain areas associated with higher cognitive functions; the forebrain, midbrain and hindbrain areas associated with the control of movement; and in hindbrain areas associated with the control of motor and sensory functions of the autonomic nervous system. This is consistent with the fact that cannabis has many different effects on mental function.